Article 8

Horizontal and Vertical Ridge Augmentation in the Aesthetic Zone

 

Asian Journal of Oral Implantology & Tissue Regeneration 2018

Jan- Jun;01(1):34-37

 

Lanka Mahesh, Sandeep Singh, Sagrika Shukla, India

INTRODUCTION

A long-standing edentulous space results in bone resorption, creating a bony defect jeopardizing implant placement. For the very same reason, various bone grafts are available which improve the quality of bone for implant placement. There are 4 types of grafts,  autograft, harvested from the patient itself, allografts, harvested from same species, xenografts, harvested from different species and aloplasts, which are synthetic bone grafts. Autograft is the gold standard, for the rest of the graft types, apart from being osteoconductive, each has specific quality to be used depending upon case to case.

 

Allografts,  though  one  of  the  most  commonly used grafts which provide an osteoconductive surface along with source of osteoinductive  factors,1   have  disadvantages as  regenerative  properties  depend  upon donor variability limiting the predictability as an osteoinductive material2  as the bone inducing ability is age-dependent, thus older donors are less likely to have strong bone- inducing activity.3

Also, demineralization of the graft varies between tissue banks which may affect clinical regeneration.  Keeping all these factors into consideration, bovine Xenograft which is identical to human bone has gained popularity.  One such material which has shown promising results in the field of bone regeneration is bovine Xenograft (BDX) Ti-oss®.

 

CASE REPORT

A patient reported with long-standing edentulous space in relation to 21 and bone loss up to one-third of the apical portion in 22 (Fig 1). An artificial crown in relation to 21 was supported with the help composite and wire splint (Fig 1). Patient lost 21 to trauma few years ago and was willing for implant placement. Patient was healthy without any medical condition or drug allergies.

 

Clinically defect was classified as a C.2.e type  (Fig  2) according to cologne classification.4  Defect was grafted with

Ti-oss® bone graft and Titanium reinforced   Cytoplast membrane. (Immediate implants, Nobel Active 4.3/11.5 in 21 and 3.5/11.5 in 22 were placed (Fig 3). Implants were loaded after 5 months (Fig  4). Post-op one year follow up showed excellent hard and soft tissue configuration around implants without any complications (Fig 5).

DISCUSSION

As aforementioned, there are various types of grafts available each having distinct properties. Out of all, autogenous remains as the gold standard but grafts types such as allografts are also being used most commonly due to their BMP releasing ability.2 However, because of their disadvantages, a clinician is not certain of their regenerative properties. Thus, to overcome these draw-backs, Xenografts have become a popular choice. BDX is considered identical to the human bone.5,6  And has several characteristics and advantages when compared with freeze-dried demineralized bone such as no donor site is required from the patients, age-dependent regenerative capacity is no longer a disadvantage, unlimited supplies of the material are available; the material can be easily handled and has predictable results.7  Other advantages are that it is 100% deproteinated and crystalline hydroxyapatite grafting material which is considered biocompatible7 and is very well tolerated, and without any adverse reactions or allergies reported so far.

 

Several studies have shown that DBX has excellent osteoconductive properties facilitates angiogenesis and migration of osteoblasts.8-11   Various histological studies have also shown that with time BDX particles were surrounded by mature, compact bone and in some Haversian canals, it was possible to observe small capillaries, mesenchymal cells, and osteoblasts in conjunction with new bone and the BDX granules being interconnected by bridges of vital newly formed bone.12 With time, BDX  becomes integrated and subsequently replaced by newly formed bone.6 It has been reported that BDX in spite of having a very low resorption rate13 it has shown enhanced osteoblast activity to promote bone formation. Because of these properties, it can be used for ridge augmentations and also with immediate implants.


CONCLUSION
Xenograft Ti-oss® bone graft material shows good results and can be used in large defects without any complications. Immediate implants can also be placed along with the bone graft which and results shows excellent hard and soft tissue healing around implants.

REFERENCES
 
1. Position paper. Tissue banking of bone allografts used in periodontal regeneration. J Periodontol 2001;72:834-8.
2. Boyan BD, Ranly DM, Schwartz Z. Use of growth factors to modify osteoinductivity of demineralized bone allografts: lessons for tissue engineering of bone. Dent Clin North Am 2006;50:217–28.
3. Schwartz Z, Somers A, Mellonig JT, Carnes DL Jr, Dean DD, Cochran DL, Boyan BD.
Ability of commercial demineralized freeze-dried
bone allograft to induce new bone formation is dependent on donor age but not gender. J Periodontol1998;69:470–78.
4. Ehrl P, Fürst U, Happe A, Khoury F, Kobler P, Konstantinovic V et al. Cologne Classification of Alveolar Ridge Defects (
CCARD). 2013:1-10.
5. Berglundh T, Lindhe J. Healing around implants placed in bone defects treated with Bio-Oss. An experimental study in the dog. Clin Oral Implants Res 1997;8:117–124.
6. Piattelli A, Podda G, Scarano A. Clinical and histological results in alveolar ridge enlargement using coralline calcium carbonate. Biomaterials 1997;18:623–627.
7. Callan DP, Rohrer MD. Use of bovine-derived hydroxyapatite in the treatment of edentulous ridge defects: a human clinical and histologic case report. J Periodontol1993;64:575–582.
8. Mellonig J. Human histologic evaluation of a bovine derived xenograft in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent 2002;20:19–29.
9. Zitzmann NU, Scharer P, Marinello CP, Schupbach P, Berglundh T. Alveolar ridgementation with Bio- Oss: a histologic study in humans. Int J Periodontics Restorative Dent 2001;21:288–295.
10. Paolantonio M. Combined periodontal regenerative technique in human intrabony defects by collagen membranes and anorganic bovine bone. A controlled clinical study. J Periodontol2002;73:158–166.
11. Orsini G, Traini T, Scarano A, Degidi M, Perrotti  V, Piccirilli M, Piattelli A. Maxillary sinusmentation with Bio-Oss particles: a light, scanning, and
transmission electron microscopy study in man. J Biomed Mater Res B ApplBiomater2005;74:448–457.
12. Tadjoedin ES, de Lange GL, Bronckers AL, Lyaruu DM, Burger EH.Deproteinizedcancellous bovine bone (Bio-Oss) as bone substitute
for sinus floor elevation. A retrospective, histomorphometrical study of five cases. J ClinPeriodontol2003;30:261–270.
13. Valentini P, Abensur D. Maxillary sinus floor elevation for implant placement with demineralized freeze-dried bone and bovine bone (Bio-Oss): a clinical study of 20 patients. Int J Periodontics Restorative Dent 1997;17:232–241.

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