Rabbit Tibia 12 Weeks Comparison Study
Between Ti-oss® (Chiyewon Co.) & OCS-B (Nibec Co.)
Yonsei Unversity, Department of Dental Biomaterial & Bioengineering
This rabbit study was executed at Yonsei University in 2011 to compare the new bone formation ratio between two products; 1. Ti-oss® (Chiyewon co.) 2. OCSB® (Nibec co.) which has been approved by FDA (Equimatrix, Osteohealth) and KFDA (OCSB, Nibec co.) to sell. The study design was to make the same size of bone holes at each tibia and place the same volume of two graft materials into each hole. 12 weeks after surgical placement, Biopsy were taken to examine the condition of bone formation.
For comparison purposes, left-Ti-oss®, right-OCSB. arranged.
Please click on the images for a comfortable view.
This study proved safety and biocompatibility of Ti-oss® as a bone substitute material. Significantly higher bone formation seems to be related to osteoconductive undamaged osteoblast preferred topograph of Ti-oss®, similar to human bone, due to low heat processing technique and PH control technique. High heat process technique (1,100-1,300’c, 2-3 hours) seriously alters the surface topograph, resulting in glassification. This simplifies the manufacturing difficulties, but collagen network does not form well on glassified surface which is closely related to the bone formation ratio.