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Rabbit Tibia 12 Weeks Comparison Study

Between Ti-oss®​ (Chiyewon Co.) & OCS-B (Nibec Co.)

 

Yonsei Unversity, Department of Dental Biomaterial & Bioengineering
Seoul, Korea
2011
 

 PURPOSE

This rabbit study was executed at Yonsei University in 2011 to compare the new bone formation ratio between two products; 1. Ti-oss® (Chiyewon co.) 2. OCSB® (Nibec co.) which has been approved by FDA (Equimatrix, Osteohealth) and KFDA (OCSB, Nibec co.) to sell. The study design was to make the same size of bone holes at each tibia and place the same volume of two graft materials into each hole. 12 weeks after surgical placement, Biopsy were taken to examine the condition of bone formation.

 

For comparison purposes, left-Ti-oss®, right-OCSB. arranged.

 

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DISCUSSION

This study proved safety and biocompatibility of Ti-oss® as a bone substitute material. Significantly higher bone formation seems to be related to osteoconductive undamaged osteoblast preferred topograph of Ti-oss®, similar to human bone, due to low heat processing technique and PH control technique. High heat process technique (1,100-1,300’c, 2-3 hours) seriously alters the surface topograph, resulting in glassification. This simplifies the manufacturing difficulties, but collagen network does not form well on glassified surface which is closely related to the bone formation ratio.

Ti-oss® SEM x 3000
Ti-oss® SEM x 3000

Unglassified Osteoconductive

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Cerabone
Cerabone

Surface all melted & glassified same as bone ceramic

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Octacalcium phosphate is the very hot issue in bone biology as this may reduce the healing time in implantology by fast bone formation on this preHA crystal. SEM study revealed the existence of octacalcium phosphate crystal on Ti-oss® surface and this may explain excellent and very thin new bone formation all around on Ti-oss® biopsy samples in 4 months

Ti-oss® angiogenic structure
Ti-oss® angiogenic structure
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Endobone porous nature damaged
Endobone porous nature damaged
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OCSB (Nibec) all cortical particles
OCSB (Nibec) all cortical particles
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